Bennett B B
Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, USA.
Obstet Gynecol. 1997 May;89(5 Pt 2):832-3. doi: 10.1016/s0029-7844(97)00036-7.
Misoprostol (prostaglandin E1) compares favorably with dinoprostone (prostaglandin E2) and oxytocin for labor induction at term. Excessive uterine activity has been reported using high-dose regimens, but no negative effect on outcomes has been observed.
Labor was induced in a 34-year-old multipara at 39 weeks' gestation using intravaginal misoprostol tablets. Five hours after administration of the second 25-microgram dose, fetal bradycardia prompted emergency cesarean delivery. Hysterectomy and left salpingo-oophorectomy were necessary to control bleeding from a 15-cm posterior uterine wall rupture.
Misoprostol can cause excessive uterine activity and uterine rupture.
