Department of Obstetrics and Gynaecology, School of Medical Sciences, University of Campinas, SP, Brazil.
Bull World Health Organ. 2011 Sep 1;89(9):657-65. doi: 10.2471/BLT.08.061226. Epub 2011 Jul 5.
To assess the frequency of elective induction of labour and its determinants in selected Latin America countries; quantify success in attaining vaginal delivery, and compare rates of caesarean and adverse maternal and perinatal outcomes after elective induction versus spontaneous labour in low-risk pregnancies.
Of 37,444 deliveries in women with low-risk pregnancies, 1847 (4.9%) were electively induced. The factors associated with adverse maternal and perinatal outcomes among cases of spontaneous and induced onset of labour were compared. Odds ratios for factors potentially associated with adverse outcomes were calculated, as were the relative risks of having an adverse maternal or perinatal outcome (both with their 95% confidence intervals). Adjustment using multiple logistic regression models followed these analyses.
Of 11,077 cases of induced labour, 1847 (16.7%) were elective. Elective inductions occurred in 4.9% of women with low-risk pregnancies (37,444). Oxytocin was the most common method used (83% of cases), either alone or combined with another. Of induced deliveries, 88.2% were vaginal. The most common maternal adverse events were: (i) a higher postpartum need for uterotonic drugs, (ii) a nearly threefold risk of admission to the intensive care unit; (iii) a fivefold risk of postpartum hysterectomy, and (iv) an increased need for anaesthesia/analgesia. Perinatal outcomes were satisfactory except for a 22% higher risk of delayed breastfeeding (i.e. initiation between 1 hour and 7 days postpartum).
Caution is mandatory when indicating elective labour induction because the increased risk of maternal and perinatal adverse outcomes is not outweighed by clear benefits.
评估在选定的拉丁美洲国家中选择性引产的频率及其决定因素;量化阴道分娩的成功率,并比较低危妊娠中选择性引产与自发性分娩后剖宫产和不良母婴围产结局的发生率。
在低危妊娠的 37444 例分娩中,有 1847 例(4.9%)为选择性引产。比较自发性和诱导性分娩病例中与不良母婴围产结局相关的因素。计算与不良结局相关的潜在因素的优势比,以及发生不良母婴结局的相对风险(均带有 95%置信区间)。采用多元逻辑回归模型进行调整后进行这些分析。
在 11077 例诱导分娩中,有 1847 例(16.7%)为选择性引产。在低危妊娠妇女中,4.9%(37444 例)行选择性引产。催产素是最常用的方法(83%的病例),单独使用或与其他方法联合使用。在诱导分娩中,88.2%为阴道分娩。最常见的产妇不良事件是:(i)产后需要使用宫缩药物的可能性增加;(ii)入住重症监护病房的风险增加近三倍;(iii)产后子宫切除的风险增加五倍;(iv)需要麻醉/镇痛的可能性增加。围产结局令人满意,除了母乳喂养延迟的风险增加 22%(即产后 1 小时至 7 天开始母乳喂养)。
在选择性引产时必须谨慎,因为增加的母婴不良结局风险并没有明显的益处来抵消。