Urticaria and angioedema. A simple approach to a complex problem.

Urticaria is a complex problem for both primary care practitioners and patients. Patients often present in considerable distress, with pruritus and uncomfortable lesions. They are frightened and frustrated about their condition and are searching for answers. Attempting to identify the cause by evaluating patient medications, contacts, and dietary history can be challenging. A multitude of laboratory tests can be performed, but they often do not provide a diagnosis. Skin allergy testing is frequently difficult at this stage. A working knowledge of the underlying pathology and causes of urticaria is essential during diagnosis. Astute evaluation can provide the clues necessary to accurately identify and treat the problem with available medications and modalities.