Aliotta A, Pompili M, Rapaccini G L, De Vitis I, Caputo S, Cedrone A, Grattagliano A, Gasbarrini G
Istituto di Medicina Interna e Geriatria, Università Cattolica del Sacro Cuore, Rome, Italy.
J Ultrasound Med. 1997 Feb;16(2):85-91; quiz 93-4. doi: 10.7863/jum.1997.16.2.85.
We studied, by means of Doppler ultrasonography, the blood flow in the superior mesenteric artery in 12 untreated patients with celiac disease (nontropical sprue) and in 15 healthy controls; peak systolic velocity, end diastolic velocity, mean velocity, flow volume, and resistive index were measured in the fasting state and at regular intervals after ingestion of 0.5 liter of water containing 50 g of saccharose. Under fasting conditions, celiac patients showed peak systolic velocity, end diastolic velocity, mean velocity, and flow volume values significantly higher than those of normal subjects, whereas resistive index was significantly lower. After saccharose ingestion these parameters showed greater variations in normal subjects than in celiac patients. Fasting end diastolic velocity turned out to be the best parameter to distinguish celiac patients from healthy subjects. Doppler ultrasonography of the superior mesenteric artery could discriminate between normal subjects and celiac patients with overt disease. However, these data need further confirmation given the limited sample that we studied; moreover, the capability of this technique in distinguishing nontropical sprue from other gastrointestinal diseases that cause increasing splanchnic flow remains to be ascertained.
我们通过多普勒超声检查，研究了12例未经治疗的乳糜泻（非热带性口炎性腹泻）患者和15名健康对照者肠系膜上动脉的血流情况；在空腹状态下以及摄入含有50克蔗糖的0.5升水后定期测量收缩期峰值流速、舒张末期流速、平均流速、血流量和阻力指数。在空腹条件下，乳糜泻患者的收缩期峰值流速、舒张末期流速、平均流速和血流量值显著高于正常受试者，而阻力指数则显著较低。摄入蔗糖后，这些参数在正常受试者中的变化比在乳糜泻患者中更大。空腹舒张末期流速被证明是区分乳糜泻患者和健康受试者的最佳参数。肠系膜上动脉的多普勒超声检查可以区分正常受试者和患有明显疾病的乳糜泻患者。然而，鉴于我们研究的样本有限，这些数据需要进一步证实；此外，该技术在区分非热带性口炎性腹泻与其他导致内脏血流增加的胃肠道疾病方面的能力仍有待确定。
