Sato K, Kioi S, Arakawa M
Department of Medicine (II), Niigata University School of Medicine, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1997 Mar;35(3):288-93.
We used multiple regression analysis to study the effects of smoking cessation on the decline in forced expiratory volume in one second (FEV1). We studied 429 healthy men for about 3 years. Each subject was assigned to one of three groups, according to their self-reported smoking history: 281 were current smokers, 67 were former smokers, and 81 had never smoked. After statistical adjustment for initial age, initial FEV1, and decline in Maximum Mid-expiratory Flow (MMF), current smoking was found to be associated with a faster decline in FEV1. Having stopped smoking was associated with a slower decline in FEV1. The rate of decline in MMF was associated with the rate of decline in FEV1, which suggests that the rate of decline in FEV1 was greater in those subjects with small airways disease.
我们使用多元回归分析来研究戒烟对一秒用力呼气量（FEV1）下降的影响。我们对429名健康男性进行了约3年的研究。根据他们自我报告的吸烟史，每个受试者被分配到三组中的一组：281名是当前吸烟者，67名是既往吸烟者，81名从未吸烟。在对初始年龄、初始FEV1和最大呼气中期流速（MMF）下降进行统计调整后，发现当前吸烟与FEV1下降更快有关。戒烟与FEV1下降较慢有关。MMF的下降速率与FEV1的下降速率相关，这表明小气道疾病患者的FEV1下降速率更大。
