新型重组丝氨酸蛋白酶抑制剂（LEX032）对人白细胞蛋白酶3的抑制作用
Inhibition of human leukocyte proteinase 3 by a novel recombinant serine proteinase inhibitor (LEX032).
作者信息
Groutas W C, Ruan S, Kuang R, Hook J B, Sands H
机构信息
Department of Chemistry, Wichita State University, Kansas 67260, USA.
出版信息
Biochem Biophys Res Commun. 1997 Apr 28;233(3):697-9. doi: 10.1006/bbrc.1997.6526.
PMID:9168917
Abstract
The interaction of a bioengineered serpin (LEX032) with human leukocyte proteinase 3 (PR 3) has been investigated. LEX032 was found to be a time-dependent inhibitor of PR 3, forming a highly-stable enzyme-inhibitor complex (Ki 12 nM).
摘要
已对一种生物工程丝氨酸蛋白酶抑制剂（LEX032）与人白细胞蛋白酶3（PR 3）的相互作用进行了研究。发现LEX032是PR 3的时间依赖性抑制剂，可形成高度稳定的酶-抑制剂复合物（Ki为12 nM）。
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