Wascher T C, Posch K, Wallner S, Hermetter A, Kostner G M, Graier W F
Department of Internal Medicine, University of Graz, Austria.
Biochem Biophys Res Commun. 1997 May 8;234(1):35-8. doi: 10.1006/bbrc.1997.9994.
L-arginine supplementation is hypothesized to reduce endothelial dysfunction and atherogenesis via increased biosynthesis of nitric oxide. Here we describe superoxide scavenging properties of arginine as an additional aspect which needs to be considered. Furthermore, arginine reduced copper-induced lipid peroxidation, indicating that superoxide anions essentially contribute to this process. In intact endothelial cells, L-arginine but not D-arginine diminished superoxide release and reduced cell-mediated breakdown of nitric oxide. Our data indicate that the reported vascular effects of L-arginine supplementation might involve an increased bioavailability of nitric oxide due to its superoxide scavenging properties beside a potential increased NO biosynthesis.
补充L-精氨酸被认为可通过增加一氧化氮的生物合成来减轻内皮功能障碍和动脉粥样硬化的发生。在此，我们描述精氨酸的超氧化物清除特性，这是需要考虑的另一个方面。此外，精氨酸减少了铜诱导的脂质过氧化，表明超氧阴离子在这一过程中起重要作用。在完整的内皮细胞中，L-精氨酸而非D-精氨酸可减少超氧化物的释放，并减少细胞介导的一氧化氮分解。我们的数据表明，补充L-精氨酸所报告的血管效应可能不仅涉及一氧化氮生物合成的潜在增加，还因其超氧化物清除特性而增加了一氧化氮的生物利用度。
