Christie D R, Kirk J A, Clarke C L, Boyages J
Division of Radiation Oncology, Westmead Hospital, NSW, Australia.
Cancer Genet Cytogenet. 1997 Jun;95(2):159-62. doi: 10.1016/s0165-4608(96)00218-x.
A family is presented in whom hereditary angioedema (HAE) and hereditary breast cancer were coexistent, an association not previously reported. A potential for genetic and treatment-related interactions between the two conditions exists. The use of the hormonal agent danazol to suppress HAE is unlikely to adversely affect the development or outcome of breast cancer. Surgery, chemotherapy, and radiotherapy were received by affected family members, without triggering edema. Whether hormonal breast cancer treatment affects the suppression of HAE by danazol remains unknown.
本文报道了一个家族，其中遗传性血管性水肿（HAE）与遗传性乳腺癌并存，此前尚未有这种关联的报道。这两种疾病之间存在基因和治疗相关相互作用的可能性。使用激素药物达那唑抑制HAE不太可能对乳腺癌的发生或预后产生不利影响。患病家族成员接受了手术、化疗和放疗，并未引发水肿。激素性乳腺癌治疗是否会影响达那唑对HAE的抑制作用尚不清楚。
