McCloskey G L, Massa M C
Loyola University Medical Center, Division of Dermatology, Maywood, Illinois 60153, USA.
Cutis. 1997 May;59(5):251-4.
The ampicillin rash occurring in cases of infectious mononucleosis is well documented. Similar phenomena have also been observed with other antibiotics. The case of a patient with infectious mononucleosis treated with cephalexin who later showed a rash is presented and the previous literature is reviewed. The rash seen in this patient, who was treated with cephalexin, may be similar to the rash seen with ampicillin treatment of patients with infectious mononucleosis. The mechanism by which these eruptions occur is not completely understood, although there are many interesting theories. Perhaps rashes during infectious mononucleosis in association with other antibiotics are actually more common, but just not recognized. A heightened awareness of this possibility may therefore lead to recognition of more cases and further understanding of this entity.
传染性单核细胞增多症病例中出现的氨苄西林皮疹已有充分记录。在使用其他抗生素时也观察到了类似现象。本文报告了1例接受头孢氨苄治疗的传染性单核细胞增多症患者随后出现皮疹的病例，并对既往文献进行了综述。该接受头孢氨苄治疗的患者出现的皮疹，可能与氨苄西林治疗传染性单核细胞增多症患者时出现的皮疹相似。尽管有许多有趣的理论，但这些皮疹发生的机制尚未完全明确。也许传染性单核细胞增多症患者在使用其他抗生素时出现皮疹的情况实际上更为常见，只是未被认识到。因此，提高对这种可能性的认识可能会发现更多病例，并进一步了解这一现象。
