Holtzman D, Meyers R, Khait I, Jensen F
Department of Neurology, Children's Hospital, Boston, MA, USA.
Epilepsy Res. 1997 Apr;27(1):7-11. doi: 10.1016/s0920-1211(96)01019-4.
Brain creatine kinase (CK) catalyzed phosphorus fluxes between phosphocreatine (PCr) and ATP and changes in reactant concentrations were measured using [31P] nuclear magnetic resonance spectroscopy ([31P]NMR) before and during pentylenetetrazole-induced seizures in 7 and 21 day old rats. The CK rate constants measured before seizures were three times higher in the older than in the younger rats. The rate constants increased 60% during seizures in the older rats but did not change or decreased in the younger. Small decreases in PCr were seen during seizures at both ages. A small decrease in ATP was seen at 7 days but not at 21 days.
