一名恶性淋巴瘤患者自体外周血干细胞移植后发生的溶血性尿毒症综合征

Hemolytic uremic syndrome following autologous peripheral blood stem cell transplantation in a patient with malignant lymphoma.

作者信息

Ohno E, Ohtsuka E, Iwashita T, Uno N, Ogata M, Kikuchi H, Nasu M

机构信息

Second Department of Internal Medicine, Oita Medical University, Hasama-machi, Japan.

出版信息

Bone Marrow Transplant. 1997 May;19(10):1045-7. doi: 10.1038/sj.bmt.1700791.

DOI:10.1038/sj.bmt.1700791

PMID:9169652

Abstract

Hemolytic uremic syndrome (HUS) has been reported in patients receiving bone marrow transplantation. However, only a few cases of HUS following autologous peripheral blood stem cell transplantation (PBSCT) have been reported. We present a case of HUS developing after autologous PBSCT in a 40-year-old man with non-Hodgkin's lymphoma. It appears that the chemotherapeutic agents administered during the conditioning regimen for PBSCT may have played an important role in the development of HUS in our patient. In the present case, the combination therapy of vincristine, methylprednisolone, and ticlopidine hydrochloride was effective.

摘要

接受骨髓移植的患者中曾有溶血性尿毒症综合征（HUS）的报道。然而，自体外周血干细胞移植（PBSCT）后发生HUS的病例仅有少数报道。我们报告了1例40岁非霍奇金淋巴瘤男性患者在自体PBSCT后发生HUS的病例。看来，在PBSCT预处理方案中使用的化疗药物可能在该患者HUS的发生中起了重要作用。在本病例中，长春新碱、甲泼尼龙和盐酸噻氯匹定的联合治疗有效。