Roubidoux M A, Helvie M A, Wilson T E, Lai N E, Paramagul C
Department of Radiology, University of Michigan Medical Center, Ann Arbor 48109-0326, USA.
Radiology. 1997 Jun;203(3):691-4. doi: 10.1148/radiology.203.3.9169690.
To investigate contralateral breast biopsy histologic findings in women with breast cancer.
Histologic findings in 237 patients with breast cancer who underwent contralateral breast biopsy for clinically or mammographically detected abnormalities were retrospectively reviewed. Malignant findings were categorized by histologic type. Benign findings were categorized by risk of breast cancer. Comparison was made with mammographically guided breast biopsy results in 1,294 patients without breast cancer.
Of the 237 patients, 168 (70.9%) had either malignancy or high-risk histologic findings. One hundred thirty-nine patients (58.6%) had malignant findings; 98 (41.4%) had benign findings. Of the 98 with benign findings, 29 (30%) had high-risk histologic findings. Thirty (33%) of the 91 patients with invasive cancer had invasive lobular carcinoma. Forty-seven (45.6%) of the 103 patients with malignant lesions at mammographically guided biopsies had ductal carcinoma in situ alone.
Compared with biopsy in women without breast cancer, contralateral biopsy in women with breast cancer was more likely to show malignancy, invasive lobular carcinoma, or ductal carcinoma in situ alone (P < .001) or to show high-risk histologic benign findings (P < .001). Mammographic and clinical findings in the contralateral breast should be regarded as more suspicious than those in patients without known breast cancer.
研究乳腺癌患者对侧乳腺活检的组织学结果。
回顾性分析237例因临床或乳腺X线检查发现异常而接受对侧乳腺活检的乳腺癌患者的组织学结果。恶性结果按组织学类型分类。良性结果按患乳腺癌风险分类。并与1294例无乳腺癌患者的乳腺X线引导下乳腺活检结果进行比较。
237例患者中，168例（70.9%）有恶性或高危组织学结果。139例（58.6%）有恶性结果；98例（41.4%）有良性结果。在98例有良性结果的患者中，29例（30%）有高危组织学结果。91例浸润性癌患者中有30例（33%）为浸润性小叶癌。103例乳腺X线引导下活检有恶性病变的患者中，47例（45.6%）仅为导管原位癌。
与无乳腺癌女性的活检相比，乳腺癌女性的对侧活检更可能显示恶性、浸润性小叶癌或仅导管原位癌（P <.001），或显示高危组织学良性结果（P <.001）。应认为对侧乳腺的乳腺X线和临床检查结果比已知无乳腺癌患者的结果更可疑。
