化脓性链球菌M24血清型向M5和M18血清型的转变：对吞噬作用抗性及与宿主细胞黏附的影响
Conversion of M serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18: effect on resistance to phagocytosis and adhesion to host cells.
作者信息
Courtney H S, Liu S, Dale J B, Hasty D L
机构信息
Department of Veterans Affairs Medical Center and Department of Medicine, University of Tennessee, Memphis 38104, USA.
出版信息
Infect Immun. 1997 Jun;65(6):2472-4. doi: 10.1128/iai.65.6.2472-2474.1997.
Abstract
In this study, we utilized recombinant strains expressing the M5 and M18 proteins and M- mutants of group A streptococci to compare the abilities of these M proteins to confer resistance to phagocytosis and to mediate adhesion to host cells. The data indicate that the M5 and M18 proteins can confer resistance to phagocytosis, that fibrinogen is required for this resistance, and that these M proteins can mediate adhesion to HEp-2 cells.
摘要
在本研究中，我们利用表达M5和M18蛋白的重组菌株以及A组链球菌的M - 突变体，比较这些M蛋白赋予抗吞噬作用的能力以及介导与宿主细胞粘附的能力。数据表明，M5和M18蛋白可赋予抗吞噬作用，这种抗性需要纤维蛋白原，并且这些M蛋白可介导与HEp - 2细胞的粘附。
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