Arp蛋白是M蛋白家族的成员之一，其表达不足以抑制化脓性链球菌的吞噬作用。
Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes.
作者信息
Husmann L K, Scott J R, Lindahl G, Stenberg L
机构信息
Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322.
出版信息
Infect Immun. 1995 Jan;63(1):345-8. doi: 10.1128/iai.63.1.345-348.1995.
Abstract
Many Streptococcus pyogenes immunoglobulin-binding proteins have structural similarities to the antiphagocytic M protein, including the well-known C repeats. One of these molecules is the immunoglobulin A-binding protein Arp, which is expressed by a serotype 4 strain for which no antiphagocytic M protein has yet been described. We expressed Arp4 in an S. pyogenes strain from which the structural gene for the M protein has been deleted and found that Arp4 is not sufficient to inhibit phagocytosis.
摘要
许多化脓性链球菌免疫球蛋白结合蛋白与抗吞噬的M蛋白具有结构相似性，包括众所周知的C重复序列。其中一种分子是免疫球蛋白A结合蛋白Arp，它由4型菌株表达，而该菌株尚未发现有抗吞噬的M蛋白。我们在一个已缺失M蛋白结构基因的化脓性链球菌菌株中表达了Arp4，发现Arp4不足以抑制吞噬作用。
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Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes.Arp蛋白是M蛋白家族的成员之一，其表达不足以抑制化脓性链球菌的吞噬作用。
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