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Arp蛋白是M蛋白家族的成员之一，其表达不足以抑制化脓性链球菌的吞噬作用。

Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes.

作者信息

Husmann L K, Scott J R, Lindahl G, Stenberg L

机构信息

Department of Microbiology and Immunology, Emory University, Atlanta, Georgia 30322.

出版信息

Infect Immun. 1995 Jan;63(1):345-8. doi: 10.1128/iai.63.1.345-348.1995.

DOI:10.1128/iai.63.1.345-348.1995
PMID:7806375
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC172998/
Abstract

Many Streptococcus pyogenes immunoglobulin-binding proteins have structural similarities to the antiphagocytic M protein, including the well-known C repeats. One of these molecules is the immunoglobulin A-binding protein Arp, which is expressed by a serotype 4 strain for which no antiphagocytic M protein has yet been described. We expressed Arp4 in an S. pyogenes strain from which the structural gene for the M protein has been deleted and found that Arp4 is not sufficient to inhibit phagocytosis.

摘要

许多化脓性链球菌免疫球蛋白结合蛋白与抗吞噬的M蛋白具有结构相似性，包括众所周知的C重复序列。其中一种分子是免疫球蛋白A结合蛋白Arp，它由4型菌株表达，而该菌株尚未发现有抗吞噬的M蛋白。我们在一个已缺失M蛋白结构基因的化脓性链球菌菌株中表达了Arp4，发现Arp4不足以抑制吞噬作用。

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Expression of the Arp protein, a member of the M protein family, is not sufficient to inhibit phagocytosis of Streptococcus pyogenes.Arp蛋白是M蛋白家族的成员之一，其表达不足以抑制化脓性链球菌的吞噬作用。
Infect Immun. 1995 Jan;63(1):345-8. doi: 10.1128/iai.63.1.345-348.1995.
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本文引用的文献

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Current knowledge of type-specific M antigens of group A streptococci.A组链球菌特定类型M抗原的现有知识。
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An M protein with a single C repeat prevents phagocytosis of Streptococcus pyogenes: use of a temperature-sensitive shuttle vector to deliver homologous sequences to the chromosome of S. pyogenes.具有单个C重复序列的M蛋白可阻止化脓性链球菌的吞噬作用：利用温度敏感穿梭载体将同源序列导入化脓性链球菌染色体。
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Common protective antigens of group A streptococcal M proteins masked by fibrinogen.被纤维蛋白原掩盖的A组链球菌M蛋白的常见保护性抗原。
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