Miller-Podraza H, Milh M A, Teneberg S, Karlsson K A
Department of Medical Biochemistry, Göteborg University, Sweden.
Infect Immun. 1997 Jun;65(6):2480-2. doi: 10.1128/iai.65.6.2480-2482.1997.
Two standard strains of Helicobacter pylori, grown on solid or in liquid medium, were studied for their binding to sialic acid-containing glycosphingolipids on thin-layer plates. NCTC 11637, but not strain 11638, bound to mixtures of gangliosides of various human and animal origins with similar binding patterns and also to polyglycosylceramides of human erythrocytes, leukocytes, and placenta. There was an apparent specificity for NeuAc alpha3Gal of the neolacto series of gangliosides, since NeuAc alpha6Gal or ganglio-series gangliosides did not bind.
对在固体或液体培养基上培养的两种幽门螺杆菌标准菌株进行了研究,以观察它们与薄层板上含唾液酸的糖鞘脂的结合情况。NCTC 11637菌株(而非11638菌株)能与各种人和动物来源的神经节苷脂混合物以相似的结合模式结合,还能与人红细胞、白细胞及胎盘的多聚糖基神经酰胺结合。对新乳糖系列神经节苷脂的NeuAcα3Gal存在明显的特异性,因为NeuAcα6Gal或神经节系列神经节苷脂不结合。