Frank D A, Greenberg M E
Department of Neurology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Perspect Dev Neurobiol. 1996;4(1):3-18.
Neuropoietic cytokines such as ciliary neurotrophic factor, leukemia inhibitory factor, and interleukin-6 are known to be responsible for a wide variety of effects on cells of the immune and nervous systems. The mechanisms by which such diverse effects are regulated and coordinated within cells is of central importance to the understanding of how these molecules function during development. This review discusses the receptor complexes through which neuropoietic cytokines signal and the mechanisms by which activation of specific enzymes such as the Jak family of kinases are transduced into changes of gene expression through molecules such as the Stat proteins. This review also discusses how this JAK-Stat signaling pathway is thought to interact with other known cascades, such as the mitogen-activated protein kinase pathway.
神经生成细胞因子，如睫状神经营养因子、白血病抑制因子和白细胞介素-6，已知对免疫和神经系统的细胞具有多种作用。这些多样的作用在细胞内如何被调节和协调的机制，对于理解这些分子在发育过程中的功能至关重要。本综述讨论了神经生成细胞因子发出信号所通过的受体复合物，以及诸如Jak激酶家族等特定酶的激活如何通过Stat蛋白等分子转导为基因表达变化的机制。本综述还讨论了这种JAK-Stat信号通路被认为如何与其他已知的级联反应相互作用，如丝裂原活化蛋白激酶通路。
