Finn T, Nishi R
Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland 97201, USA.
Perspect Dev Neurobiol. 1996;4(1):91-9. doi: 10.1080/0907676x.1996.9961276.
Ciliary neurotrophic factor (CNTF) was first identified as a trophic activity that was able to support the survival of chick ciliary ganglion (CG) neurons in vitro. CNTF from rabbit and rat were subsequently purified from sciatic nerve and their cDNA sequences cloned. Another trophic molecule for CG neurons was identified as a growth promoting activity (GPA). GPA was purified from chicken sciatic nerve and cloned from embryonic chicken eye. The rat and rabbit CNTFs have a considerable amount of structural homology and are not secreted in significant quantities, whereas GPA is less similar in that it is only 49% homologous with rabbit and rat CNTF and is secreted by cells. This review discusses other similarities and differences in biological activities, molecular structure, receptor signaling and cellular distribution between CNTF and GPA and suggests that these molecules may have different functions in rodents and birds.
睫状神经营养因子（CNTF）最初被鉴定为一种能够在体外支持鸡睫状神经节（CG）神经元存活的营养活性物质。随后从兔和大鼠的坐骨神经中纯化出CNTF，并克隆了它们的cDNA序列。另一种针对CG神经元的营养分子被鉴定为生长促进活性物质（GPA）。GPA从鸡坐骨神经中纯化，并从鸡胚眼中克隆得到。大鼠和兔的CNTF具有相当程度的结构同源性，且分泌量不大，而GPA与之不太相似，它与兔和大鼠的CNTF仅有49%的同源性，且由细胞分泌。这篇综述讨论了CNTF和GPA在生物活性、分子结构、受体信号传导及细胞分布方面的其他异同，并表明这些分子在啮齿动物和鸟类中可能具有不同的功能。
