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在资源有限的条件下使用局部盐酸甲磺灭脓(磺胺米隆)喷雾剂治疗烧伤。

The management of burns under conditions of limited resources using topical aqueous sulfamylon (mafenide) hydrochloride spray.

作者信息

Mendelson J A

出版信息

J Burn Care Rehabil. 1997 May-Jun;18(3):238-44. doi: 10.1097/00004630-199705000-00011.

DOI:10.1097/00004630-199705000-00011
PMID:9169948
Abstract

The burn unit establishment in a Vietnamese military hospital (1970 to 1971) is an example of the management of burns under conditions of limited resources. The problems encountered and methods used in their solution are still relevant. This is the first (and possibly still the only) instance of such clinical use of topical Sulfamylon (mafenide) aqueous spray as the sole pregraft antibacterial agent for patients with deep partial-thickness and full-thickness burns (and associated injuries). The mafenide spray open treatment resulted in a bacteriostatic film permitting eschars to remain uninfected while more superficial burns healed and general status improved, enabling delayed grafting to be effective. Use of operating rooms, supplies, and personnel was minimized. The study group contained 211 patients; 86 (approximately 40%) had burns that exceeded 20% body surface area, and 26 (approximately 12%) had burns that exceeded 40% body surface area. As the procedures became fully established, all of the last 110 patients of this series survived. Only 17 deaths occurred in the total series; none were attributed to infection.

摘要

越南一家军事医院于1970年至1971年设立烧伤科,是资源有限情况下烧伤治疗的一个范例。当时遇到的问题及解决方法至今仍有借鉴意义。这是首次(可能也是唯一一次)将局部应用磺胺米隆(甲磺灭脓)水性喷雾剂作为深Ⅱ度和Ⅲ度烧伤(及相关损伤)患者植皮前唯一抗菌剂的临床应用实例。磺胺米隆喷雾开放式治疗形成了抑菌膜,使焦痂未受感染,而较浅度烧伤愈合,全身状况改善,从而使延迟植皮有效。手术室、物资和人员的使用降至最低限度。研究组有211例患者;86例(约40%)烧伤面积超过体表面积的20%,26例(约12%)烧伤面积超过40%。随着治疗程序完全确立,该系列最后110例患者全部存活。整个系列仅17例死亡;无一例归因于感染。

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