加拿大的肾癌：成人和老年人中腺癌发病率迅速上升。
Kidney cancer in Canada: the rapidly increasing incidence of adenocarcinoma in adults and seniors.
作者信息
Liu S, Semenciw R, Morrison H, Schanzer D, Mao Y
机构信息
Laboratory Centre for Disease Control, Health Canada, Ottawa, ON.
出版信息
Can J Public Health. 1997 Mar-Apr;88(2):99-104. doi: 10.1007/BF03403870.
PURPOSE
To examine kidney cancer incidence and mortality patterns since 1969 in Canada.
METHOD
Linear regression of the log rates was used to estimate secular trends by age group and sex, and age-period-cohort models were fitted to examine changes in kidney cancer and renal adenocarcinoma incidence rates.
RESULTS
A substantial increase in incidence rates was observed among those 35 years and older, with average increases of 2.5% or more annually for both sexes. Age-period-cohort modelling suggested that much of this increase resulted from a period effect. Changes in mortality were much more modest, especially among those aged 0-34, for whom mortality rates actually declined by an average of 4.2% and 5.4% annually for males and females respectively.
CONCLUSIONS
Kidney cancer incidence rates have increased significantly, especially renal adenocarcinoma among adults and seniors. Diagnostic improvements and increasing levels of obesity in the Canadian population may have contributed to these trends.
目的
研究1969年以来加拿大肾癌的发病率和死亡率模式。
方法
采用对数发病率的线性回归来估计不同年龄组和性别的长期趋势，并拟合年龄-时期-队列模型以研究肾癌和肾腺癌发病率的变化。
结果
35岁及以上人群的发病率显著上升，男女年均增幅均达2.5%或更高。年龄-时期-队列模型表明，这种上升很大程度上是由时期效应导致的。死亡率变化较为温和，尤其是0-34岁人群，男性和女性的死亡率实际上分别以年均4.2%和5.4%的幅度下降。
结论
肾癌发病率显著上升，尤其是成人和老年人中的肾腺癌。诊断水平的提高和加拿大人口肥胖率的上升可能促成了这些趋势。
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