Lerman C, Schwartz M D, Lin T H, Hughes C, Narod S, Lynch H T
Department of Medicine, Georgetown University Medical Center, Washington, DC 20007-4104, USA.
J Consult Clin Psychol. 1997 Jun;65(3):414-20. doi: 10.1037//0022-006x.65.3.414.
The recent identification of BRCA1, a breast cancer susceptibility gene, offers an unprecedented opportunity for high-risk individuals to learn whether they are genetically predisposed to develop breast or ovarian cancer. This study examined the relationships between psychological distress and use of BRCA1 testing by 149 high-risk individuals from hereditary cancer families. After a baseline assessment of demographics, objective risk, cancer-specific distress, and global distress (depressive symptoms), study participants were offered the opportunity to receive genetic counseling and to learn whether they carry a mutation in the BRCA1 gene. Overall, 58% of study participants requested BRCA1 test results, and 42% declined to learn their genetic status. After controlling for demographic factors and risk status, cancer-specific distress was significantly and positively related to BRCA1 test use, whereas global distress was unrelated to test use.
近期对乳腺癌易感基因BRCA1的鉴定，为高危个体提供了前所未有的机会，让他们了解自己是否在基因上易患乳腺癌或卵巢癌。本研究调查了149名来自遗传性癌症家族的高危个体的心理困扰与BRCA1检测使用之间的关系。在对人口统计学、客观风险、癌症特异性困扰和总体困扰（抑郁症状）进行基线评估后，研究参与者有机会接受遗传咨询，并了解自己是否携带BRCA1基因突变。总体而言，58%的研究参与者要求获得BRCA1检测结果，42%的人拒绝了解自己的基因状况。在控制了人口统计学因素和风险状况后，癌症特异性困扰与BRCA1检测的使用显著正相关，而总体困扰与检测的使用无关。
