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山羊胰岛素诱导的低血糖与脑电图

Insulin-induced hypoglycemia and the electroencephalogram in goats.

作者信息

Itabisashi T

出版信息

Natl Inst Anim Health Q (Tokyo). 1977 Fall;17(3):107-14.

PMID:917124
Abstract

The effect of insulin-induced hypoglycemia on the cortical electroencephalogram was examined in adult goats and kids. Adult goats were injected subcutaneously with 8 or 12 units/kg of insulin or intravenously with 1.2 to 10 units/kg. From a certain level between 15 and 25 mg/dl of blood glucose downwards, marked slowing of electroencephalogram was evident. When the blood glucose level was below 15 mg/dl, abnormal behaviors severer than lassitude appeared. They included inability of standing, twitching of face muscles, writhing, stupor and severe twitching of the head. No tetanic convulsions were observed in the present 8-hour experiments. When kids were injected subcutaneously with 8 units/kg of insulin, they showed the same relations among blood glucose level, electroencephalogram and behavior as the adult goats. They manifested abnormal behaviors, including tetanic convulsions.

摘要

在成年山羊和幼羊中研究了胰岛素诱导的低血糖对皮质脑电图的影响。成年山羊皮下注射8或12单位/千克胰岛素,或静脉注射1.2至10单位/千克胰岛素。从血糖水平在15至25毫克/分升之间的某一水平开始下降,脑电图明显减慢。当血糖水平低于15毫克/分升时,出现比倦怠更严重的异常行为。这些行为包括无法站立、面部肌肉抽搐、翻滚、昏迷和头部剧烈抽搐。在目前8小时的实验中未观察到强直性惊厥。当给幼羊皮下注射8单位/千克胰岛素时,它们在血糖水平、脑电图和行为之间表现出与成年山羊相同的关系。它们表现出异常行为,包括强直性惊厥。

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