Wadsworth E J, Shield J P, Hunt L P, Baum J D
Institute of Child Health, Bristol, UK.
Diabet Med. 1997 May;14(5):390-6. doi: 10.1002/(SICI)1096-9136(199705)14:5<390::AID-DIA364>3.0.CO;2-E.
In 1992 a national case-control study was conducted through the British Paediatric Association Surveillance Unit (BPASU) framework to evaluate both the incidence of IDDM in children under 5 in that year and the effects of various putative trigger factors in the disease pathogenesis. A total of 218 sets of matched case-control questionnaire data established that paternal IDDM (odds ratio (OR) = 16.11, 95% confidence interval (CI) 1.94-133.7, p < = 0.001) is independently associated with increased risk, and higher birth order (OR = 0.64, CI 0.44-0.94, p = 0.021) and paternal age greater than 25 years (age 25-39 OR = 0.52, CI 0.30-0.89; age 40 + OR = 0.23, CI 0.08-0.67, p = 0.009) with decreased risk of diabetes. Other factors previously implicated in the disease pathogenesis (birthweight, parental socio-economic status, infant feeding, and immunization record) showed no significant independent association with disease development.
1992年，通过英国儿科学会监测单位（BPASU）框架开展了一项全国性病例对照研究，以评估当年5岁以下儿童中胰岛素依赖型糖尿病（IDDM）的发病率以及该疾病发病机制中各种假定触发因素的影响。总共218组匹配的病例对照问卷调查数据表明，父亲患IDDM（比值比（OR）= 16.11，95%置信区间（CI）1.94 - 133.7，p <= 0.001）与患病风险增加独立相关，而出生顺序较高（OR = 0.64，CI 0.44 - 0.94，p = 0.021）以及父亲年龄大于25岁（25 - 39岁OR = 0.52，CI 0.30 - 0.89；40岁及以上OR = 0.23，CI 0.08 - 0.67，p = 0.009）与糖尿病风险降低相关。先前在疾病发病机制中涉及的其他因素（出生体重、父母社会经济地位、婴儿喂养和免疫记录）与疾病发展无显著独立关联。
