[The diagnostic and therapeutic significance of thrombocyte functional activity and the factors in its regulation in chronic diseases of the large intestine].

To elucidate diagnostic value of platelet functional activity in chronic colon disease, we studied ADP-induced platelet aggregation (PA, in vitro) and cAMP concentration in blood plasma. If patients had chronic catarrhal, ulcerative colitis or chronic colon stasis, their serum cAMP appeared low, while initial rate of ADP-induced PA was high. The above alterations varied with the disease severity, in exacerbation and remission. CAMP, histamine and epinephrine were tried as regulators of platelet activity. Phosphodiesterase inhibitor trental proved efficient in the treatment of chronic colon diseases. It has improved clinical condition of the patients, inhibited the initial rate of ADP-induced PA, secured its partial or complete reversibility through a rise in plasma and platelet cAMP concentrations.