Khadzhiev A K, Inogamov T A, Dautov F A, Khadzhieva Kh N, Askarov U A, Navruzov S N
Ter Arkh. 1997;69(2):32-4.
To elucidate diagnostic value of platelet functional activity in chronic colon disease, we studied ADP-induced platelet aggregation (PA, in vitro) and cAMP concentration in blood plasma. If patients had chronic catarrhal, ulcerative colitis or chronic colon stasis, their serum cAMP appeared low, while initial rate of ADP-induced PA was high. The above alterations varied with the disease severity, in exacerbation and remission. CAMP, histamine and epinephrine were tried as regulators of platelet activity. Phosphodiesterase inhibitor trental proved efficient in the treatment of chronic colon diseases. It has improved clinical condition of the patients, inhibited the initial rate of ADP-induced PA, secured its partial or complete reversibility through a rise in plasma and platelet cAMP concentrations.
为阐明血小板功能活性在慢性结肠疾病中的诊断价值，我们研究了二磷酸腺苷（ADP）诱导的血小板聚集（体外）及血浆中环磷酸腺苷（cAMP）浓度。患有慢性卡他性、溃疡性结肠炎或慢性结肠淤滞的患者，其血清cAMP水平较低，而ADP诱导的血小板聚集初始速率较高。上述改变随疾病严重程度、病情加重及缓解情况而变化。试用了cAMP、组胺及肾上腺素作为血小板活性调节剂。磷酸二酯酶抑制剂曲克芦丁在慢性结肠疾病治疗中被证明有效。它改善了患者的临床状况，抑制了ADP诱导的血小板聚集初始速率，并通过提高血浆及血小板cAMP浓度使血小板聚集部分或完全可逆。
