多发性硬化症患者体内的人疱疹病毒6型免疫球蛋白G抗体
Human herpesvirus-6 immunoglobulin G antibodies in patients with multiple sclerosis.
作者信息
Nielsen L, Larsen A M, Munk M, Vestergaard B F
机构信息
Department of Virology, Statens Seruminstitut, Copenhagen, Denmark.
出版信息
Acta Neurol Scand Suppl. 1997;169:76-8. doi: 10.1111/j.1600-0404.1997.tb08154.x.
OBJECTIVE
To further investigate a possible correlation between human herpesvirus-6 (HHV-6) infection and multiple sclerosis by analyzing the level of HHV-6 antibodies in MS patients and healthy controls.
MATERIALS AND METHODS
A total of 189 serum samples from patients with multiple sclerosis (MS) in different disease stages and 190 serum samples from healthy controls matched for age and sex were analyzed for HHV-6 antibodies using a competitive ELISA.
RESULTS
There was no difference between HHV-6 IgG titers in MS patients and controls. Two of the controls were seronegative for HHV-6 versus to none of the MS-patients. There was no apparent difference in HHV-6 titers from patients in different disease stages.
CONCLUSION
This study cannot support the theory that HHV-6 is a contributing factor to the development of MS, although a seroprevalence study like this would not disclose whether a late primary infection (in puberty) with HHV-6 might affect the development of MS.
目的
通过分析多发性硬化症（MS）患者和健康对照者中人类疱疹病毒6型（HHV - 6）抗体水平，进一步研究HHV - 6感染与多发性硬化症之间可能存在的相关性。
材料与方法
使用竞争性酶联免疫吸附测定法（ELISA），对189份来自处于不同疾病阶段的多发性硬化症（MS）患者的血清样本以及190份来自年龄和性别匹配的健康对照者的血清样本进行HHV - 6抗体分析。
结果
MS患者和对照者中HHV - 6 IgG滴度无差异。两名对照者的HHV - 6血清学检测呈阴性，而MS患者中无此情况。不同疾病阶段患者的HHV - 6滴度无明显差异。
结论
本研究不支持HHV - 6是MS发病的一个促成因素这一理论，尽管这样的血清流行率研究无法揭示青春期的HHV - 6初次感染是否可能影响MS的发病。
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