Coughlan C, McAuliffe F, Bermingham N, Gleeson N
Dept of Obstetrics & Gynaecology (Gynaecological Oncology), Coombe Women's Hospital, Dublin.
Ir J Med Sci. 2006 Jan-Mar;175(1):45-9. doi: 10.1007/BF03169000.
Vaginal intraepithelial neoplasia (VAIN) is usually detected in patients with synchronous or antecedent cervical or vulval intraepithelial or invasive cancer. VAIN has the potential to progress to malignancy.
To determine the incidence and severity and analyse the management of vaginal dysplasia in patients undergoing primary hysterectomy for cervical cancer.
A retrospective study (1984-1998) identified 210 primary invasive cervical cancers. One-hundred and twenty-three patients had a primary hysterectomy.
In follow-up six patients were found to have dyskaryosis in a second vaginal smear. Biopsies in the six patients with colposcopic lesions showed VAIN II (n=2), VAIN III (n=1),VAIN III / possible early invasion (n = 1) and invasive carcinoma (n=2). One patient with recurrent squamous cancer received salvage radiotherapy and one with recurrent adenocarcinoma received high dose progestogens and topical 5-fluorouracil.
All patients are disease-free at follow-up.
阴道上皮内瘤变（VAIN）通常在患有同步或先前宫颈或外阴上皮内或浸润性癌的患者中被检测到。VAIN有进展为恶性肿瘤的可能。
确定宫颈癌患者行根治性子宫切除术中阴道发育异常的发生率和严重程度，并分析其处理方法。
一项回顾性研究（1984 - 1998年）确定了210例原发性浸润性宫颈癌患者。其中123例行根治性子宫切除术。
随访中，6例患者在第二次阴道涂片检查中发现核异常。6例阴道镜检查有病变的患者活检显示为VAIN II（n = 2）、VAIN III（n = 1）、VAIN III / 可能早期浸润（n = 1）和浸润性癌（n = 2）。1例复发性鳞状癌患者接受了挽救性放疗，1例复发性腺癌患者接受了大剂量孕激素和局部5 - 氟尿嘧啶治疗。
所有患者随访时均无疾病。
