宫颈发育异常女性血浆中HPV感染频率及谷胱甘肽水平
Frequency of HPV infection and GSH levels in plasma of women with cervical dysplasia.
作者信息
Kwaśniewska A, Tukendorf A, Semczuk M
机构信息
I Clinic of Obstetrics and Gynecology, Lublin Medical Academy, Poland.
出版信息
Eur J Gynaecol Oncol. 1997;18(3):196-9.
Human papillomavirus (HPV) can be a cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The level of antioxidant compounds in plasma (retinol, alfa-tocoferol, vitamins C and E, glutathione) can modulate the progression of latent HPV infection to subclinical lesions and CIN. Our studies show that in the cases of HPV infection glutathione (GSH) content decreased, but glutathione disulfide (GSSG) levels increased. The quantitative GSH/GSSG ratio reflects the above changes of both peptides which, the more distinct, the greater the pathological changes in the uterine cervix.
人乳头瘤病毒（HPV）可能是宫颈上皮内瘤变（CIN）和宫颈癌的病因。血浆中抗氧化化合物（视黄醇、α-生育酚、维生素C和E、谷胱甘肽）的水平可调节潜伏性HPV感染向亚临床病变和CIN的进展。我们的研究表明，在HPV感染的病例中，谷胱甘肽（GSH）含量降低，但二硫化谷胱甘肽（GSSG）水平升高。GSH/GSSG定量比值反映了上述两种肽的变化，其差异越明显，子宫颈的病理变化就越大。
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