Horvath T L, Garcia-Segura L M, Naftolin F
Yale University School of Medicine, Department of Obstetrics and Gynecology, New Haven, CT, USA.
Gynecol Endocrinol. 1997 Apr;11(2):139-43. doi: 10.3109/09513599709152525.
The preovulatory gonadotropin surge is a critical event in reproduction. Although many explanations have been given for the inhibition--disinhibition cycle referred to as positive feedback, none are completely satisfactory. Recent evidence indicates that the preovulatory surge of gonadotropin is induced, in part, by the disengagement of inhibitory synaptic connections in the hypothalamic arcuate nucleus. This disinhibition of gonadotropin-releasing hormone secretion results in a massive release by the estrogen-sensitized pituitary gonadotrophs. Investigations are presently under way to determine whether other areas of the hypothalamus are involved in this estrogen-induced synaptic plasticity.
排卵前促性腺激素激增是生殖过程中的一个关键事件。尽管对于被称为正反馈的抑制 - 去抑制循环已经给出了许多解释，但没有一个是完全令人满意的。最近的证据表明，促性腺激素的排卵前激增部分是由下丘脑弓状核中抑制性突触连接的脱离所诱导的。促性腺激素释放激素分泌的这种去抑制导致雌激素敏感的垂体促性腺细胞大量释放。目前正在进行调查，以确定下丘脑的其他区域是否参与这种雌激素诱导的突触可塑性。
