Spanggaard H, Knudsen U B, Uldbjerg N, Jeziorska M, Woolley D E, Danielsen C C
Department of Obstetrics and Gynaecology, Aarhus Kommunehospital, Denmark.
Eur J Obstet Gynecol Reprod Biol. 1997 May;73(1):91-7. doi: 10.1016/s0301-2115(97)02735-8.
Cervical ripening purportedly involves different cell types and mediators normally associated with inflammatory reactions. The purpose of the present study was to determine the presence of mast cells in rat cervices during spontaneous and antigestagen induced ripening and to test whether a mast cell stabilizer was able to inhibit the antigestagen induced cervical ripening. Immunohistochemical examinations demonstrated an increased number of mast cells in pregnant and intrapartum rats. Furthermore, mast cell degranulation was found to be prominent after antigestagen treatment. The degranulation was completely abolished by co-treatment with the mast cell stabilizer. Biomechanical analysis showed that the mast cell stabilizer also inhibited the antigestagen induced cervical ripening to some extent. Thus, it is concluded that mast cell stabilizers might constitute a new approach in the treatment of preterm cervical ripening.
宫颈成熟据称涉及通常与炎症反应相关的不同细胞类型和介质。本研究的目的是确定在自然和抗孕激素诱导的成熟过程中大鼠宫颈中肥大细胞的存在，并测试肥大细胞稳定剂是否能够抑制抗孕激素诱导的宫颈成熟。免疫组织化学检查显示，怀孕和分娩时大鼠的肥大细胞数量增加。此外，发现抗孕激素治疗后肥大细胞脱颗粒明显。与肥大细胞稳定剂共同处理可完全消除脱颗粒。生物力学分析表明，肥大细胞稳定剂在一定程度上也抑制了抗孕激素诱导的宫颈成熟。因此，得出结论，肥大细胞稳定剂可能构成治疗早产宫颈成熟的一种新方法。
