Stiemer B, Elger W
Department of Obstetrics and Gynecology, Free University of Berlin, Germany.
J Perinat Med. 1990;18(6):419-29. doi: 10.1515/jpme.1990.18.6.419.
The circumstances which cause the ripening of the cervix during the initial phase of parturition are still unexplored. In addition, complications during labour such as cervical dystocia still necessitate cesarian section. Therefore we examined the biomechanical alterations of the cervix during the last trimester of pregnancy. We developed a special method to measure dilatation and resistance of the rat cervix. After testing several substances, the antigestagen Mifepristone turned out to be most effective in causing cervical softening. Further investigations with light and scanning electron microscopy showed an increase of collagen and a possible loosening of collagen fibers after antigestagen treatment. Therefore it might be possible to use Mifepristone, perhaps in combination with a prostaglandin to promote cervical ripening when certain obstetric problems arise.
分娩初期导致宫颈成熟的情况仍未得到充分研究。此外，分娩过程中的并发症，如宫颈难产，仍需要进行剖宫产。因此，我们研究了妊娠晚期宫颈的生物力学变化。我们开发了一种特殊方法来测量大鼠宫颈的扩张和阻力。在测试了几种物质后，抗孕激素米非司酮被证明在引起宫颈软化方面最有效。进一步的光镜和扫描电镜研究表明，抗孕激素治疗后胶原蛋白增加，胶原纤维可能松解。因此，当出现某些产科问题时，也许可以使用米非司酮，可能与前列腺素联合使用，以促进宫颈成熟。
