Forest M G
Padiatr Padol Suppl. 1977(5):13-28.
The plasma androgens testosterone (T) and delta(4)-androstenedione (delta(4)) were measured by RIA in 245 children under 1 year of age, in 70 children of prepubertal age, and in 250 adolescents during puberty. The values presented in the tables, and their changing relation to each other, suggest, that 1. at birth T and delta(4) are of fetal origin demonstrating the important endocrine function of the fetal testis; 2. after 6 months of age there is no significant endocrine activity of the gonads any more; 3. the prepubertal activation of the adrenal androgens production (adrenarche) is similar in the 2 sexes but their chronology is different for each androgen: an increase is observed after age 8 for delta(4), after age 10 for T. 4. in puberty the increase of T- and delta(4)-values differs markedly according to the two sexes. So, while the gradual prepubertal maturation of androgen steroid production, passing the stage of "adrenal puberty", could be demonstrated convincingly, the role of the different androgens in the maturation of the "gonadostat" (hypothalamopituitary complex) still remains a matter of hypothesis.
采用放射免疫分析法（RIA）对245名1岁以下儿童、70名青春期前儿童和250名青春期青少年的血浆雄激素睾酮（T）和δ4-雄烯二酮（δ4）进行了测定。表格中呈现的值及其相互间的变化关系表明：1. 出生时，T和δ4源自胎儿，这显示了胎儿睾丸重要的内分泌功能；2. 6个月龄后，性腺不再有显著的内分泌活动；3. 青春期前肾上腺雄激素分泌的激活（肾上腺初现）在两性中相似，但每种雄激素的时间顺序不同：δ4在8岁后升高，T在10岁后升高。4. 在青春期，T和δ4值的升高在两性间有显著差异。因此，虽然可以令人信服地证明雄激素类固醇分泌在青春期前逐渐成熟，并经过了“肾上腺青春期”阶段，但不同雄激素在“性腺调节系统”（下丘脑-垂体复合体）成熟过程中的作用仍只是一种假设。
