大鼠纹状体细胞外抗坏血酸对非挥发性麻醉剂给药的反应变化。
Changes in extracellular brain ascorbate in rat striatum in response to administration of non-volatile anaesthetic agents.
作者信息
Miele M, Fillenz M
机构信息
University Laboratory of Physiology, Oxford, UK.
出版信息
Br J Anaesth. 1997 May;78(5):588-90. doi: 10.1093/bja/78.5.588.
We used constant potential in vivo voltammetry to measure changes in striatal ascorbate in the rat in response to i.p. administration of several non-volatile anaesthetics. Propofol and pentobarbitone, which enhance GABA-mediated neuronal inhibitions, decreased ascorbate current to 27.0 (SEM 7.4) % and 46 (6) % of control, respectively. Chloral hydrate, diazepam alone or with ketamine, and fentanyl-fluanisone with midazolam produced no changes in ascorbate current.
我们采用恒电位体内伏安法来测量大鼠纹状体抗坏血酸的变化，以响应几种非挥发性麻醉剂的腹腔注射。丙泊酚和戊巴比妥可增强GABA介导的神经元抑制作用，分别使抗坏血酸电流降至对照的27.0（标准误7.4）%和46（6）%。水合氯醛、单独使用或与氯胺酮联用的地西泮，以及与咪达唑仑联用的芬太尼-氟胺酮均未引起抗坏血酸电流的变化。
Zotero 插件