Kosco-Vilbois M H, Bonnefoy J Y, Chvatchko Y
Immunology Department, Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S.A., Switzerland.
Immunol Rev. 1997 Apr;156:127-36. doi: 10.1111/j.1600-065x.1997.tb00964.x.
Germinal center responses are the mechanism that the immune system uses normally to generate high affinity antigen-specific B-cell receptors and secreted immunoglobulins. Genetically altered mice have provided powerful tools for dissecting the physiology of these germinal center responses. In this review, we have attempted to summarize information from various sources and interpret the new observations based on what was previously known. A section is included to review the basic anatomy of the relevant structures in lymph node and spleen. A summary of the mutant mice producing a phenotype where germinal center responses are altered is also furnished. This review is aimed at providing useful information to those working in this field as well as those wishing to understand more about in vivo immunology.
生发中心反应是免疫系统通常用于产生高亲和力抗原特异性B细胞受体和分泌型免疫球蛋白的机制。基因工程改造的小鼠为剖析这些生发中心反应的生理学提供了强大的工具。在这篇综述中，我们试图总结来自各种来源的信息，并根据先前已知的内容解释新的观察结果。其中有一部分内容回顾了淋巴结和脾脏中相关结构的基本解剖学知识。还提供了产生生发中心反应改变表型的突变小鼠的总结。这篇综述旨在为该领域的研究人员以及那些希望更深入了解体内免疫学的人员提供有用的信息。
