Hutchinson S, Logan R
Portsmouth Healthcare NHS Trust, Queen Alexandra Hospital, UK.
Age Ageing. 1997 Mar;26(2):87-9. doi: 10.1093/ageing/26.2.87.
to test whether omeprazole taken for longer than 1 month causes an increase in the rate of small bowel bacterial overgrowth in elderly subjects.
44 elderly people, 22 taking omeprazole, 22 not taking omeprazole or H2 receptor antagonists.
rate of positive glucose-hydrogen breath tests; anthropometric measures and blood tests reflecting malabsorption.
there was no difference in the rate of positive tests between those taking omeprazole (45%) and those not taking it (59%). The omeprazole group had significantly lower serum albumin concentrations. There was no difference in body mass index, mid-arm circumference, arm fold thickness, adjusted calcium concentration or haemoglobin levels.
omeprazole does not cause increased bacterial shall bowel overgrowth in elderly subjects.
检测服用奥美拉唑超过1个月是否会导致老年受试者小肠细菌过度生长率增加。
44名老年人，22名服用奥美拉唑，22名未服用奥美拉唑或H2受体拮抗剂。
葡萄糖-氢呼气试验阳性率；反映吸收不良的人体测量指标和血液检测。
服用奥美拉唑者（45%）和未服用者（59%）的试验阳性率无差异。奥美拉唑组血清白蛋白浓度显著较低。体重指数、上臂围、臂褶厚度、校正钙浓度或血红蛋白水平无差异。
奥美拉唑不会导致老年受试者小肠细菌过度生长增加。
