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[毒鹅膏中毒患者血清中鹅膏毒素的测定(作者译)]

[The determination of amanitines in the serum of patients poisoned by amanita phalloides (author's transl)].

作者信息

Busi C, Fiume L, Costantino D, Borroni M, Ambrosino G, Olivotto A, Bernardini D

出版信息

Nouv Presse Med. 1977 Oct 1;6(32):2855-7.

PMID:917801
Abstract

The serum of patients suffering from Amanita phalloides poisoning was analysed in order to determine whether amanitines, which are the principal toxins of this fungus, were still present in the blood at the time of hospitalisation. In addition, the authors measured the concentrations of amanitines in the blood of dogs at different intervals after the ingestion of a fatal dose of Amanita phalloides. Amanitines were detected in the serum of 9 patients out of 16. This discovery, together with the finding that, in the dog, very low concentrations of amanitines in the blood are associated with fatal cellular lesions, suggests the need for very prompt action in order to eliminate these toxins from the blood as soon as the diagnosis of poisoning is suspected.

摘要

对毒蝇伞中毒患者的血清进行了分析,以确定作为这种真菌主要毒素的鹅膏毒素在入院时血液中是否仍然存在。此外,作者测量了摄入致命剂量毒蝇伞后不同时间间隔的犬血液中鹅膏毒素的浓度。16名患者中有9名患者的血清中检测到了鹅膏毒素。这一发现,连同在犬身上的发现,即血液中极低浓度的鹅膏毒素与致命的细胞损伤有关,表明一旦怀疑中毒诊断,就需要立即采取行动以便尽快从血液中清除这些毒素。

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