Ferri A, Calza R
Department of Biochemistry and Molecular Biology University of Ferrara.
Boll Soc Ital Biol Sper. 1996 Nov-Dec;72(11-12):295-301.
Platelet aggregation is accompanied with reorganization of contractile systems. This event involves tyrosine phosphorylation of various proteins. When tyrosine phosphorylation is induced by an intracellular trigger as vanadate, a phosphorylated cytosolic 60 Kd protein acts as a nucleating center on which new actin filaments grow. When aggregation is induced by an extracellular signal as ristocetin, actin filaments of the membrane-associated skeleton and the 60 Kd protein bound to this structure migrate toward the cytosol and only in this soluble state the 60 Kd protein undergoes tyrosine phosphorylation and consequently triggers reorganization of contractile systems.
血小板聚集伴随着收缩系统的重组。这一过程涉及多种蛋白质的酪氨酸磷酸化。当酪氨酸磷酸化由细胞内触发剂如钒酸盐诱导时，一种磷酸化的胞质60千道尔顿蛋白充当成核中心，新的肌动蛋白丝在其上生长。当聚集由细胞外信号如瑞斯托菌素诱导时，膜相关骨架的肌动蛋白丝和与该结构结合的60千道尔顿蛋白向胞质溶胶迁移，只有在这种可溶状态下，60千道尔顿蛋白才会发生酪氨酸磷酸化，从而触发收缩系统的重组。
