Toh U, Yamana H, Nakao M, Imai Y, Seki N, Takasu H, Kaneshige T, Fujita H, Shirouzu K, Itoh K
First Department of Surgery, Kurume University School of Medicine, Asahi-machi, Japan.
Cell Immunol. 1997 May 1;177(2):137-43. doi: 10.1006/cimm.1997.1105.
This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HLA-A26- and HLA-A33-restricted and squamous cell carcinoma (SCC)-specific CTL; case 2, HLA-Cw0102-restricted and esophageal SCC-specific CTL; case 3, HLA-A24- and HLA-A26-restricted CTL recognizing histologically different tumor cells; and case 4, HLA-A26-restricted and esophageal SCC-specific CTL. These results suggest the existence of HLA class I-restricted and tumor-specific CTL in metastatic esophageal SCC.
本文研究了食管癌肿瘤部位是否存在HLA I类限制性和肿瘤特异性细胞毒性T淋巴细胞（CTL）。通过用白细胞介素-2培养肿瘤浸润淋巴细胞，从转移性淋巴结或胸腔积液中建立了5条CTL系：病例1和病例5，HLA - A26和HLA - A33限制性及鳞状细胞癌（SCC）特异性CTL；病例2，HLA - Cw0102限制性及食管SCC特异性CTL；病例3，识别组织学上不同肿瘤细胞的HLA - A24和HLA - A26限制性CTL；病例4，HLA - A26限制性及食管SCC特异性CTL。这些结果表明转移性食管SCC中存在HLA I类限制性和肿瘤特异性CTL。
