[人类白细胞抗原（HLA）表型与可溶性 HLA Ⅰ类分子血清浓度之间的相关性研究]
[A study of the association between HLA phenotype and serum concentration of soluble HLA class I].
作者信息
Matsuura H, Jimbo S, Miyamura M, Katano M, Togashi K, Matsuda J
机构信息
Mitsubishi Kagaku Bio--Clinical Laboratories, Inc.
出版信息
Nihon Rinsho Meneki Gakkai Kaishi. 1997 Apr;20(2):102-7. doi: 10.2177/jsci.20.102.
We investigated the association between the phenotypes of human leucocyte antigens (HLA) class I on the surface of lymphocytes and serum concentrations of soluble HLA (sHLA) in normal and Human immunodeficiency virus (HIV) infected subjects. Serum concentrations of sHLA inn normal subjects with HLA-A 24 were significantly higher than those in such subject without HLA-A 24. The similar relation was found in HIV infected subjects whose levels of sHLA significantly increased compared with that of normal subjects. These results might suggest that the mechanism which causes the increase in secretion of sHLA in HIV infected subjects does not change the association between HLA phenotype and serum concentration of sHLA.
我们研究了正常人和感染人类免疫缺陷病毒（HIV）的受试者淋巴细胞表面人类白细胞抗原（HLA）I类表型与可溶性HLA（sHLA）血清浓度之间的关联。携带HLA-A 24的正常受试者的sHLA血清浓度显著高于不携带HLA-A 24的此类受试者。在HIV感染受试者中也发现了类似关系，他们的sHLA水平与正常受试者相比显著升高。这些结果可能表明，导致HIV感染受试者中sHLA分泌增加的机制并未改变HLA表型与sHLA血清浓度之间的关联。
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