过敏性鼻炎患者血清中可溶性 HLA-G 及 HLA-A、-B、-C 的水平
Soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis.
作者信息
Ciprandi G, Colombo B M, Contini P, Cagnati P, Pistorio A, Puppo F, Murdaca G
机构信息
DIMI, University of Genoa, Genoa, Italy.
出版信息
Allergy. 2008 Oct;63(10):1335-8. doi: 10.1111/j.1398-9995.2008.01741.x.
BACKGROUND
Allergic rhinitis (AR) is characterized by Th2-polarized immune response. Soluble HLA (sHLA) molecules play an immunomodulatory activity. So far, however, no study investigated them in AR.
OBJECTIVE
The aim of this study was to evaluate sHLA-G and sHLA-A,-B,-C serum levels in AR patients with pollen allergy and in a group of healthy controls.
METHODS
Forty-nine AR patients were enrolled. A group of healthy nonallergic subjects was considered as control. sHLA-G and sHLA-A,-B,-C serum levels were determined by immunoenzymatic method. The study was conducted during the winter, such as outside the pollen season.
RESULTS
Allergic patients had significantly higher levels of both sHLA-G (P < 0.0001) and sHLA-A,-B,-C (P = 0.011) molecules than normal controls. Moreover, there was a significant relationship between these two soluble molecules (r = 0.69) in allergic patients.
CONCLUSION
The present study provides the first evidence that both sHLA-G and sHLA-A,-B,-C serum levels are significantly increased in AR patients with pollen allergy.
背景
变应性鼻炎（AR）的特征为Th2极化免疫反应。可溶性人类白细胞抗原（sHLA）分子具有免疫调节活性。然而，迄今为止，尚无研究在AR中对其进行调查。
目的
本研究旨在评估花粉过敏的AR患者和一组健康对照者血清中sHLA-G以及sHLA-A、-B、-C的水平。
方法
纳入49例AR患者。将一组健康非过敏受试者作为对照。采用免疫酶法测定血清中sHLA-G以及sHLA-A、-B、-C的水平。该研究在冬季进行，即处于花粉季节之外。
结果
变应性患者血清中sHLA-G（P < 0.0001）和sHLA-A、-B、-C（P = 0.011）分子水平均显著高于正常对照。此外，变应性患者中这两种可溶性分子之间存在显著相关性（r = 0.69）。
结论
本研究首次提供证据表明，花粉过敏的AR患者血清中sHLA-G以及sHLA-A、-B、-C水平均显著升高。
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