花粉热、哮喘与年长同胞数量——一项双胞胎研究
Hay fever, asthma and number of older siblings--a twin study.
作者信息
Räsänen M, Laitinen T, Kaprio J, Koskenvuo M, Laitinen L A
机构信息
Department of Medicine, Helsinki University Central Hospital, Finland.
出版信息
Clin Exp Allergy. 1997 May;27(5):515-8.
BACKGROUND
It has been suggested that allergic sensitization is inversely related to the number of siblings in the family.
OBJECTIVES
To study whether a similar relation can be observed for hay fever and asthma among Finnish adolescents in a population with relatively low prevalence of atopic diseases.
METHODS
A questionnaire mailed to a nationwide sample of 1849 families with 16-year-old twins assessing the cumulative incidence of doctor-diagnosed hay fever and asthma among the adolescents and the number of older siblings in the family by parental report.
RESULTS
The cumulative incidence of hay fever was significantly lower among the adolescents with three or more older siblings (3.9%, 95% CI = 1.2-6.5%) compared with adolescents with fewer older siblings (12.7%, 95% CI = 11.4-14.0%). There was no difference in the cumulative incidence of asthma among the adolescents according to the number of older siblings in the family.
CONCLUSIONS
Large number of older siblings appears to be protective against the development of hay fever.
背景
有人提出，过敏致敏与家庭中兄弟姐妹的数量呈负相关。
目的
在特应性疾病患病率相对较低的人群中，研究芬兰青少年的花粉症和哮喘是否也存在类似关系。
方法
向全国范围内1849个有16岁双胞胎的家庭发送问卷，通过父母报告评估青少年中医生诊断的花粉症和哮喘的累积发病率以及家庭中哥哥姐姐的数量。
结果
与哥哥姐姐较少的青少年（12.7%，95%可信区间=11.4-14.0%）相比，有三个或更多哥哥姐姐的青少年中花粉症的累积发病率显著较低（3.9%，95%可信区间=1.2-6.5%）。根据家庭中哥哥姐姐的数量，青少年哮喘的累积发病率没有差异。
结论
哥哥姐姐数量多似乎对花粉症的发生有保护作用。
Zotero 插件