Eliasson B, Attvall S, Taskinen M R, Smith U
Lundberg Laboratory for Diabetes Research, Department of Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Eur J Clin Invest. 1997 May;27(5):450-6. doi: 10.1046/j.1365-2362.1997.1330680.x.
Cigarette smokers have recently been shown to exhibit insulin resistance, dyslipidaemia and markers of the insulin resistance syndrome (IRS). The aim of this study was to examine the effects of smoking cessation on insulin sensitivity and IRS. Forty male, non-obese healthy smokers participated in this open parallel study with 8 weeks of follow-up. Seventeen subjects were able to stop smoking, while 23 subjects continued to smoke and served as a controls group. Anthropometric and metabolic data were measured. Degree of insulin sensitivity was determined with the euglycaemic hyperinsulinaemic clamp technique. Smoking cessation increased insulin sensitivity and improved the lipoprotein profile in spite of a modest increase in body weight. Initial smoking habits correlated positively with the increase in BMI as well as the improvements in the metabolic variables after smoking cessation. These data support the view that smoking causes insulin resistance and IRS, and also demonstrate that the beneficial metabolic effects of smoking cessation override the effects of an accompanying modest increase in body weight.
近期研究表明，吸烟者存在胰岛素抵抗、血脂异常及胰岛素抵抗综合征（IRS）的标志物。本研究旨在探讨戒烟对胰岛素敏感性和IRS的影响。40名非肥胖健康男性吸烟者参与了这项为期8周随访的开放平行研究。17名受试者成功戒烟，23名受试者继续吸烟并作为对照组。测量了人体测量学和代谢数据。采用正常血糖高胰岛素钳夹技术测定胰岛素敏感性程度。尽管体重略有增加，但戒烟仍提高了胰岛素敏感性并改善了脂蛋白谱。初始吸烟习惯与戒烟后体重指数的增加以及代谢变量的改善呈正相关。这些数据支持吸烟会导致胰岛素抵抗和IRS的观点，同时也表明戒烟带来的有益代谢效应超过了随之而来的体重适度增加所产生的影响。
