Davidson J R, Colket J T
Duke University Medical Center, Durham, North Carolina 27710, USA.
Int Clin Psychopharmacol. 1997 Jan;12(1):41-5. doi: 10.1097/00004850-199701000-00006.
This preliminary report describes a new brief interview based assessment of post-traumatic stress disorder using an 8-item treatment-outcome post-traumatic stress disorder scale (TOP-8). The TOP-8 was developed from a larger post-traumatic stress disorder evaluation scale based on items which occurred frequently in the population and which responded substantially to treatment across time. The 8 resultant items were drawn from all three symptom clusters for post-traumatic stress disorder, and showed an improved ability to detect drug versus placebo differences in comparison with the original scale. The eight-item treatment-outcome post-traumatic stress disorder scale also correlated significantly with a self-rated measure of post-traumatic stress disorder and distinguished at a highly significant level between responders and non-responders on an independently judged Clinical Global Impressions measure. The results of this study are discussed and future directions suggested.
本初步报告描述了一种基于8项创伤后应激障碍治疗结果量表（TOP-8）的新型简短访谈式创伤后应激障碍评估方法。TOP-8是从一个更大的创伤后应激障碍评估量表发展而来，该量表基于人群中频繁出现且随时间推移对治疗有显著反应的项目。最终的8个项目取自创伤后应激障碍的所有三个症状群，与原始量表相比，在检测药物与安慰剂差异方面能力有所提高。8项创伤后应激障碍治疗结果量表还与创伤后应激障碍的自评量表显著相关，并在独立判断的临床总体印象测量中，在有反应者和无反应者之间有高度显著的区分度。本文讨论了该研究结果并提出了未来的研究方向。
