Kirchhoff M, Gerdes T, Maahr J, Rose H, Lundsteen C
Chromosome Laboratory, Juliane Marie Center Rigshospitalet, University of Copenhagen, Denmark.
Cytometry. 1997 Jun 1;28(2):130-4.
Comparative genomic hybridization (CGH) is a relatively new technique whose application is increasing. The method has mostly been employed for detection of chromosome aberrations in cancers, and a large amount of data in this field is accumulating. At the same time, efforts are made to improve the technique in order to increase the sensitivity and the generation of reliable results. Based on experimental data, we have developed a computer algorithm for eliminating some of the interfering effects of unsuppressed repetitive sequences in CGH analysis, and thereby improved our CGH analysis system.
比较基因组杂交（CGH）是一种应用日益广泛的相对较新的技术。该方法主要用于检测癌症中的染色体畸变，并且该领域的大量数据正在积累。与此同时，人们正在努力改进该技术，以提高灵敏度并产生可靠的结果。基于实验数据，我们开发了一种计算机算法，用于消除CGH分析中未抑制的重复序列的一些干扰效应，从而改进了我们的CGH分析系统。
