哒嗪氮氧化物。II. 3-氯-4-氨基甲酰基-5-芳基-6-甲基哒嗪氮氧化物的合成及体外抗菌活性评价
Pyridazine N-oxides. II. Synthesis and in vitro antimicrobial evaluation of 3-chloro-4-carbamoyl-5-aryl-6-methyl-pyridazine N-oxides.
作者信息
Gavini E, Juliano C, Mulè A, Pirisino G, Pinna G A
机构信息
Dipartimento di Scienze del Farmaco, Sassari.
出版信息
Farmaco. 1997 Jan;52(1):67-9.
PMID:9181685
Abstract
As a part of a research project on antimicrobial agents, various novel carbamoyl derivatives of pyridazine-N-oxides 7a-j were prepared in moderate to good yields from 3-chloro-4-ethoxycarbonyl-5-aryl-6-methyl-3-pyridazine. All compounds synthesized were ineffective against Gram+, Gram- bacteria and fungi while 7e and 7j exhibited a fairly good activity against Trichomonas vaginalis.
摘要
作为抗菌剂研究项目的一部分，从3-氯-4-乙氧羰基-5-芳基-6-甲基-3-哒嗪出发，以中等至良好的产率制备了各种新型哒嗪-N-氧化物7a-j的氨基甲酰基衍生物。合成的所有化合物对革兰氏阳性菌、革兰氏阴性菌和真菌均无活性，而7e和7j对阴道毛滴虫表现出相当好的活性。
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