Laghi Pasini F, Capecchi P L, Acciavatti A, Petri S, de Lalla A, Cati G, Colafati M, Di Perri T
Institute of Clinical Medicine, University of Siena, School of Medicine, Italy.
Clin Hemorheol Microcirc. 1997 Jan-Feb;17(1):73-84.
Five repeated submaximal treadmill exercises at 2 h intervals following a maximal test prolong walking distance and reduce haemorheological derangement in a second maximal test in patients affected with peripheral obliterative arterial disease (POAD). An increase in adenosine plasma levels is observed during maximal tests, thus suggesting the possibility of an ischaemic preconditioning of lower limbs. The intravenous infusion of 50-100-200 mg buflomedil, and the oral administration of 300-600-900 mg of the drug in POAD patients, also produce an increase in plasma levels of adenosine. Finally, 600 mg buflomedil orally at 12 h intervals produced pulse increase in adenosine plasma levels without any accumulation of the drug or adenosine for at least one week. The possibility of a pharmacological preconditioning of ischaemia is suggested.
对于患有外周闭塞性动脉疾病（POAD）的患者，在一次最大测试后每隔2小时进行5次重复的次最大跑步机运动，可延长步行距离，并减轻第二次最大测试中的血液流变学紊乱。在最大测试期间观察到血浆腺苷水平升高，因此提示下肢存在缺血预处理的可能性。在POAD患者中静脉输注50 - 100 - 200毫克丁咯地尔，以及口服300 - 600 - 900毫克该药物，也会使血浆腺苷水平升高。最后，每隔12小时口服600毫克丁咯地尔可使腺苷血浆水平升高，且至少一周内药物或腺苷均无蓄积。这提示了缺血药理学预处理的可能性。
