Bukharin O V, Valyshev A V
Institute of Ecology and Microorganisms Genetic, Ural Department of RAN.
Vestn Ross Akad Med Nauk. 1997(3):19-22.
The persistent properties of the intestinal microflora as a mechanism of adaptation to the host's antimicrobial factors are substantiated. The results of determination of antilysozyme and anticomplementary activities and the inactivating abilities of the bactericidal component of interferon in enteric bacteria isolated in intestinal dysbacteriosis are outlined. Changes were found in the population structure of the Escherichia flora in relation to the severity of dysbacteriosis and a high prevalence of persistent signs were revealed in enteric bacteria. There was a correlation between the persistent signs of bacteria and the severity of intestinal microbiocenotic abnormalities. The factors of microbial persistence are proposed to be used as markers of a dysbiotic process.
肠道微生物群的持久特性作为适应宿主抗菌因子的一种机制得到了证实。概述了肠道菌群失调时分离出的肠道细菌中抗溶菌酶和抗补体活性以及干扰素杀菌成分的灭活能力的测定结果。发现大肠杆菌菌群的种群结构与菌群失调的严重程度有关，并且在肠道细菌中发现了高比例的持久特征。细菌的持久特征与肠道微生物群落异常的严重程度之间存在相关性。提出将微生物持久性因素用作生态失调过程的标志物。
