Maslov L N, Lishmanov Iu B, Krylatov A V, Ugdyzhekova D S
Eksp Klin Farmakol. 1996 Nov-Dec;59(6):20-2.
When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of kappa-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the kappa-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the kappa-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of kappa-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral kappa-receptors.
以8毫克/千克的剂量腹腔注射时，κ-阿片受体的选择性激动剂U-62066在大鼠肾上腺素诱发的心律失常中表现出抗心律失常特性。在脑室内注射时，κ-激动剂U-50,488和[D-ala2]-强啡肽A(1-13)表现出促心律失常特性。κ-拮抗剂去甲二氢吗啡酮的预先给药完全消除了κ-激动剂的促心律失常和抗心律失常作用。U-62006的抗心律失常作用被认为与外周κ-受体的激活有关。
