Lishmanov Iu B, Maslov L N, Ugdyzhekova D S
Eksp Klin Farmakol. 1995 Jul-Aug;58(4):26-8.
The influence of intracerebroventricular injection of opioid peptides on the incidence and severity of ventricular arrhythmia induced by intravenous administration of epinephrine was studied. It was found that DAGO, a selective mu-agonist, and DADLE, a nonselective delta-agonist, reduce the incidence and severity of cardiac arrhythmia in rats. On the contrary, DSLET, a selective delta-agonist, and Dynorphin A 1-13 (kappa-agonist), potentiates epinephrine-induced arrhythmias. beta-Endorphin do not affect the arrhythmia. The activation of cerebral mu-opioid receptors is shown to prevent the appearance of arrhythmia. On the contrary, the activation of delta- and kappa-receptors induces the appearance of arrhythmia.
研究了脑室内注射阿片肽对静脉注射肾上腺素所致室性心律失常的发生率和严重程度的影响。结果发现，选择性μ激动剂DAGO和非选择性δ激动剂DADLE可降低大鼠心律失常的发生率和严重程度。相反，选择性δ激动剂DSLET和强啡肽A 1 - 13（κ激动剂）可增强肾上腺素诱导的心律失常。β-内啡肽对心律失常无影响。结果表明，脑内μ阿片受体的激活可预防心律失常的出现。相反，δ和κ受体的激活会诱发心律失常。
