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[拉沙热、马尔堡热、埃博拉病毒出血热及艾滋病实验室诊断中的假阳性反应]

[False-positive reactions in laboratory diagnosis of Lassa, Marburg, and Ebola viral hemorrhagic fevers and AIDS].

作者信息

Vladyko A S, Zaĭtseva V N, Trofimov N M, Shkolina T V, Scheslenok E P, Boshchenko Iu A, Petkevich A S

出版信息

Vopr Virusol. 1997 Mar-Apr;42(2):66-70.

PMID:9182402
Abstract

Sera of normal subjects and AIDS patients living in Minsk and Odessa were tested for antibodies to hazardous viral infections Lassa, Marburg, and Ebola. Four to 16% of examinees were seropositive to Ebola virus, 0.8 to 2.3% to Lassa, and up to 0.8% to Marburg virus. Common B-epitopes were found in viruses belonging to different families: Lassa, Ebola, and HIV. Antibodies specific to these viruses antigens were found in the reference sera to influenza A and B, respiratory syncytial virus, and adenovirus. Sera of convalescents after malaria and of AIDS patients contained antibodies to Lassa virus.

摘要

对明斯克和敖德萨的正常人和艾滋病患者的血清进行了检测,以查找其针对拉沙热、马尔堡和埃博拉等危险病毒感染的抗体。4%至16%的受检者对埃博拉病毒呈血清阳性,0.8%至2.3%对拉沙热呈阳性,对马尔堡病毒呈阳性的比例高达0.8%。在属于不同病毒科的病毒中发现了共同的B表位:拉沙病毒、埃博拉病毒和艾滋病毒。在甲型和乙型流感、呼吸道合胞病毒和腺病毒的参考血清中发现了针对这些病毒抗原的特异性抗体。疟疾康复者和艾滋病患者的血清中含有针对拉沙病毒的抗体。

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