Iliukhin V I, Batmanov V P
Antibiot Khimioter. 1997;42(4):21-3.
Antibiotic susceptibility of four Pseudomonas species i.e. P.aeruginosa, P.cepacia, P.mallei and P.pseudomallei was studied under conditions of different temperature and pH of the medium (within the physiologically possible deviations). It was shown that along with the general tendencies (lowered MICs at the medium alkalization) there were obvious species differences in the effect of the physicochemical factors on the Pseudomonas antibiotic resistance. The results of the study may to a certain extent serve as an explanation of the lack of coincidence of the chemotherapy efficacy with the data on the drug in vitro estimation.
研究了四种假单胞菌，即铜绿假单胞菌、洋葱伯克霍尔德菌、鼻疽假单胞菌和类鼻疽假单胞菌在培养基不同温度和pH值条件下（在生理可能的偏差范围内）的抗生素敏感性。结果表明，除了一般趋势（培养基碱化时最低抑菌浓度降低）外，物理化学因素对假单胞菌抗生素耐药性的影响存在明显的种间差异。该研究结果在一定程度上可以解释化疗疗效与药物体外评估数据不一致的原因。
