Antonov Iu V, Iliukhin V I, Popovtseva L D, Batmanov V P
Antibiot Khimioter. 1991 Jan;36(1):14-6.
Sensitivity of 184 strains of four Preudomonas species that are of importance from the medical viewpoint was studied. It was shown that all the studied strains were resistant to cefazolin and ampicillin. Sulfomonomethoxine was active only against P. mallei. Gentamicin inhibited the growth of all the strains of P. mallei and 60 per cent of the strains of P. aeruginosa. Among the four studied strains, the causative agent of glanders was the least resistant to the chemotherapeutic drugs. Eleven out of the 16 studied drugs were active against P. mallei. The strains of P. pseudomallei, the organism causing melioidosis were sensitive to 6 drugs: ceftazidime, imipenem, doxycycline, minocycline, chloramphenicol and biseptol. The dime, ceftriaxone, cefsulodin, cefoperazone, cefotaxime, piperacillin and imipenem. The strains of P. cepacia were the most resistant to all the chemotherapeutic drugs studied and only biseptol was active in the concentrations attained in blood of patients (MIC50 12.5 mg/l). 10 to 70 per cent of the strains were sensitive to ceftazidime, imipenem, doxycycline, minocycline and rifampicin. Therefore, imipenem and ceftazidime were the most active drugs with respect to the causative agents of pseudomonoses. Biseptol, doxycycline and minocycline are also worthy note.
对从医学角度来看很重要的4种假单胞菌属的184个菌株的敏感性进行了研究。结果表明，所有研究的菌株均对头孢唑林和氨苄西林耐药。磺胺间甲氧嘧啶仅对鼻疽假单胞菌有活性。庆大霉素抑制了所有鼻疽假单胞菌菌株以及60%的铜绿假单胞菌菌株的生长。在所研究的4种菌株中，鼻疽病的病原体对化疗药物的耐药性最低。16种研究药物中有11种对鼻疽假单胞菌有活性。引起类鼻疽病的类鼻疽假单胞菌菌株对6种药物敏感：头孢他啶、亚胺培南、强力霉素、米诺环素、氯霉素和复方新诺明。洋葱伯克霍尔德菌菌株对所有研究的化疗药物耐药性最强，只有复方新诺明在患者血液中达到的浓度时有活性（MIC50为12.5毫克/升）。10%至70%的菌株对头孢他啶、亚胺培南、强力霉素、米诺环素和利福平敏感。因此，就假单胞菌病的病原体而言，亚胺培南和头孢他啶是最具活性的药物。复方新诺明、强力霉素和米诺环素也值得注意。
